Calcium Sennoside a Natural Laxative
Calcium Sennoside is a standardized, naturally derived senna-based ingredient containing Sennosides A & B, the key anthraquinone glycosides responsible for its laxative activity. It is widely used as a pharmaceutical and herbal ingredient for occasional constipation relief and bowel-regulating formulations.
Product Overview
Technical profile, constituent properties and sourcing coordination
Pharmabridge offers Calcium Sennoside
standardized from 20% to 60%, with assay determined by UV and HPLC
methods, according to applicable BP & USP specifications.
Key Highlights
- Natural senna-derived ingredient
- Contains Sennoside A + Sennoside B
- Standardization available: 20%–60%
- Assay by UV and HPLC
- Suitable for pharmaceutical and herbal formulations
- Quality and specifications aligned with BP & USP
requirements, where applicable
Pharmacology of Sennoside :
Sennoside A and B, the components of senna, are metabolized by gut bacteria into the active metabolite rheinanthrone DB13175. Rheinanthrone DB13175 appears to increase cyclooxegenase 2 (COX2) expression in macrophage cells leading to an increase in prostaglandin E2 (PGE2). This increase in PGE2 is associated with a decrease in aquaporin 3 expression in mucosal epithelial cells of the large intestine. A decrease in aquaporin 3 expression likely produces the laxative effect by restricting water reabsorption by the large intestine therebyincreasing fecal water content. The exact mechanism by which rheinanthrone increases COX2 expression is unknown. Rheinanthrone DB13175 also stimulates peristalsis in the large intestine although the mechanism behind this effect is unknown. Rhein DB13174, another active metabolite is thought to excite submucosal acetylcholinergic neurons resulting in increased chloride and prostaglandin secretion. The movement of chloride ions into the large intestine would also help to draw water into the lumen.
Applications ;
Natural Laxative : Senna acts as soft purgative due to its rich Anthraquinone
Content,sitimulating colon activity by increasing peristaltic movements.
Effective weight management: senna helps in supress appetite and accelerate digestion, supporting
rapid weight loss.
Pharmabridge Advantage:
With standardized grades, analytical support, and consistent quality, Pharmabridge provides Calcium Sennoside A+B as a reliable raw material for pharmaceutical, herbal, and nutraceutical applications.
Product Specifications
Analytical parameters, chemical identity and batch verification
| Parameter | Details |
|---|---|
| Product Name | Calcium Sennoside a Natural Laxative |
| Grade / Standard | Pharma Grade |
| Physical Appearance | Standard Powder |
| Assay / Purity | Standard Specification |
Final grade, assay and batch specifications require confirmation against current manufacturer documentation and Certificates of Analysis.
Quality & Documentation Support
Analytical verification, regulatory coordination & technical records
Pharmabridge helps customers request product-specific specifications, available Certificates of Analysis (CoA), analytical methods, and safety information. Documentation availability depends on the selected product, grade, and manufacturing source.
Available Records (On Request)
- Batch Certificate of Analysis (CoA)
- HPLC / Analytical Assay Methodology
- Safety Data Sheet (SDS / MSDS)
- Impurity & Residual Solvent Information
Looking for Calcium Sennoside a Natural Laxative for Your Project?
Contact Pharmabridge with your required compound, desired assay, grade, target quantity and documentation needs. Our sourcing team coordinates specifications and commercial terms promptly.
